Compute Revised International Staging System (R-ISS)

Classifies patients into R-ISS stages based on ISS stage, cytogenetic risk group, and LDH level (Palumbo et al., JCO 2015).

Usage

compute_riss(iss_stage, risk_group, ldh = NA_real_, ldh_uln = 250)

Arguments

iss_stage

Character vector: "Stage I", "Stage II", "Stage III"

risk_group

Character vector: "High", "Standard", "high", "standard"

ldh

Numeric vector: LDH value (U/L), or NA

ldh_uln

Numeric scalar: upper limit of normal for LDH (default 250)

Value

Character vector: "R-ISS I", "R-ISS II", "R-ISS III", or NA

See also

Other cytogenetics: calculate_cooccurrence(), extract_cytogenetic_data(), plot_cooccurrence_heatmap(), plot_cytogenetic_oncoprint(), plot_expression_by_subtype(), summarize_cytogenetics()

Examples

compute_riss("Stage I", "Standard", ldh = 200)
#> [1] "R-ISS I"
compute_riss("Stage III", "High", ldh = 300)
#> [1] "R-ISS III"
compute_riss(
  c("Stage I", "Stage III", "Stage II"),
  c("Standard", "High", "Standard"),
  ldh = c(200, 300, NA)
)
#> [1] "R-ISS I"   "R-ISS III" "R-ISS II"